Overdiagnosis and overtreatment of breast cancer: Estimates of overdiagnosis from two trials of mammographic screening for breast cancer

Estimation of Overdiagnosis in Breast Cancer Screening

I. Summary The benefit of breast cancer (BC) screening with mammography has been demonstrated by randomized controlled trials (RCTs). However, there is a growing concern about the harms of screening, in particular the problem of overdiagnosis. It occurs when screening detects a breast cancer that would not have presented clinically in the woman's lifetime in the absence of screening. Overdiagno...

Overdiagnosis and Overtreatment of Prostate Cancer and Breast Cancer Due to Screening

Overdiagnosis in breast cancer chemoprevention trials.

the reduction in the use of hormone replacement therapy, and the immediacy of the effect suggests the disappearance of established subclinical cancers rather than the prevention of new cancers 23–25. The complementary observations concerning the immediate effects of tamoxifen chemoprevention and hormone replacement withdrawal suggest that a slowly growing er-positive cancer might be induced to ...

Overestimating Overdiagnosis in Breast Cancer Screening

Overdiagnosis in breast cancer has been a focus of increasing concern with wide ranges of calculations made indirectly through the study of prospective randomized trials and analyses of large registries. While most admit that some degree of overdiagnosis is inherent with ductal carcinoma in situ (DCIS), the rate of overdiagnosis with invasive disease is highly controversial. Although it is gene...

Overdiagnosis of breast cancer after 14 years of mammography screening.

BACKGROUND In 2004 we wrote in Tidsskriftet that mammography screening resulted in massive over-diagnosis and over-treatment of breast cancer. Our study was criticised because we had only five years of follow-up time and did not take account of the fact that increased use of hormone replacement therapy could lead to more breast cancer. We have now been screening women for 14 years, and during a...